Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13825360 | 0.91 | BACE1 (0.49) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL13825354 | 0.89 | BACE1 (0.49) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL13825392 | 0.87 | BACE1 (0.60) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL2283934 | 0.86 | BACE1 (0.53) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL2277036 | 0.86 | BACE1 (0.53) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL13825393 | 0.85 | BACE1 (0.52) | BACE1KCNH2CTSDBACE2APP | |
| Formic Acid SCHEMBL2281401 | 0.82 | BACE1 (0.49) | BACE1KCNH2CTSDRENBACE2 | |
| SCHEMBL3396160 | 0.80 | BACE1 (0.43) | BACE1CTSDRENBACE2 | |
| SCHEMBL13825355 | 0.79 | BACE1 (0.64) | BACE1KCNH2CTSDBACE2APP | |
| SCHEMBL2281408 | 0.78 | BACE1 (0.37) | BACE1CTSDRENBACE2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |