Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.60 |
| ▸ | CTSD | P07339 | 14/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13825326 | 0.89 | BACE1 (0.72) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL7863670 | 0.85 | BACE1 (0.80) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL13825347 | 0.82 | BACE1 (0.41) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL13825358 | 0.81 | BACE1 (0.49) | BACE1CTSDBACE2KCNH2 | |
| Formic Acid SCHEMBL2285459 | 0.81 | BACE1 (0.73) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL13825330 | 0.80 | BACE1 (0.46) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL13825504 | 0.78 | BACE1 (0.58) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL2285462 | 0.76 | BACE1 (0.57) | BACE1CTSDBACE2REN | |
| SCHEMBL13825389 | 0.76 | BACE1 (0.52) | BACE1CTSDBACE2KCNH2REN | |
| SCHEMBL2287204 | 0.75 | BACE1 (1.00) | BACE1CTSDBACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |