Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.58 |
| ▸ | CTSD | P07339 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | BACE2 | Q9Y5Z0 | 14/20 | 0.50 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13825326 | 0.86 | BACE1 (0.72) | BACE1CTSDKCNH2BACE2REN | |
| SCHEMBL7863110 | 0.84 | BACE1 (0.82) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL13825475 | 0.80 | BACE1 (0.79) | BACE1CTSDKCNH2BACE2 | |
| Formic Acid SCHEMBL2287502 | 0.79 | BACE1 (0.75) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL13825396 | 0.78 | BACE1 (0.60) | BACE1CTSDKCNH2BACE2REN | |
| SCHEMBL2287510 | 0.75 | BACE1 (0.59) | BACE1CTSDBACE2REN | |
| SCHEMBL7869151 | 0.74 | BACE1 (0.81) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2287723 | 0.74 | BACE1 (1.00) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2279151 | 0.74 | BACE1 (1.00) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2287594 | 0.72 | BACE1 (0.84) | BACE1CTSDKCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |