Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CTSD | P07339 | 8/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872671 | 0.85 | BACE1 (0.69) | BACE1CTSD | |
| SCHEMBL13825393 | 0.82 | BACE1 (0.52) | BACE1KCNH2CTSDBACE2APP | |
| SCHEMBL13825477 | 0.81 | BACE1 (0.56) | BACE1KCNH2CTSDBACE2 | |
| Formic Acid SCHEMBL2277201 | 0.81 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL2277204 | 0.76 | BACE1 (0.49) | BACE1CTSDBACE2APP | |
| SCHEMBL7863696 | 0.70 | BACE1 (0.62) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL7869263 | 0.69 | BACE1 (0.80) | BACE1CTSD | |
| SCHEMBL12376217 | 0.69 | BACE1 (0.74) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL7872518 | 0.69 | BACE1 (0.70) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL7870685 | 0.68 | BACE1 (0.57) | BACE1KCNH2CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |