Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165192 | 0.85 | CFTR (0.52) | KDM4EHSD17B10ALDH1A1HPGDHDAC1 | |
| SCHEMBL13500100 | 0.82 | CFTR (0.48) | KDM4EHSD17B10AKR1C3AKR1C2MPO | |
| SCHEMBL27669616 | 0.78 | KDM4E (0.42) | KDM4EHSD17B10AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL15958948 | 0.78 | KDM4E (0.42) | KDM4EHSD17B10AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL5168011 | 0.77 | ALDH1A1 (0.49) | KDM4EHSD17B10AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL5181564 | 0.76 | AKR1C3 (0.41) | KDM4EHSD17B10AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL11841798 | 0.74 | ALDH1A1 (0.47) | KDM4EHSD17B10ALDH1A1HPGDCFTR | |
| SCHEMBL31314547 | 0.73 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1HPGDCFTR | |
| SCHEMBL23539879 | 0.72 | KDM4E (0.46) | KDM4EHSD17B10AKR1C3AKR1C2MPO | |
| SCHEMBL20150027 | 0.72 | KDM4E (0.46) | KDM4EHSD17B10ALDH1A1HPGDCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773788-B1 | Quinazoline derivatives | NOVARTIS AG (CH) | 2012-11-14 | — | — | EP | disclosed |