Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PPM1B | O75688 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30391857 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL30122814 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL12176993 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL14771529 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL13825843 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL12176994 | 1.00 | RAB9A (0.47) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL15712143 | 0.86 | PPM1B (0.53) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL25467328 | 0.82 | PPM1B (0.50) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL3985705 | 0.82 | PPM1B (0.50) | RAB9APPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL5791356 | 0.82 | PPM1B (0.50) | RAB9APPM1BPTPN1PPP1CCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160214917-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. (NL) | 2016-07-28 | — | — | US | disclosed |
| US-20160214917-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. (NL) | 2016-07-28 | — | — | US | disclosed |
| US-9222940-B2 | Fused cyclooctyne compounds and their use in metal-free click reactions | SYNAFFIX B.V. (NL) | 2015-12-29 | — | — | US | disclosed |
| US-9222940-B2 | Fused cyclooctyne compounds and their use in metal-free click reactions | SYNAFFIX B.V. (NL) | 2015-12-29 | — | — | US | disclosed |
| EP-2894142-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SynAffix B.V. (NL) | 2015-07-15 | — | — | EP | disclosed |
| US-20150125892-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. (NL) | 2015-05-07 | — | — | US | disclosed |
| US-20150125892-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. (NL) | 2015-05-07 | — | — | US | disclosed |
| US-8889851-B2 | Methods for the synthesis and purification of oligomers | AGILENT TECHNOLOGIES, INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889851-B2 | Methods for the synthesis and purification of oligomers | AGILENT TECHNOLOGIES, INC. (US) | 2014-11-18 | — | — | US | disclosed |
| EP-2563753-B1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX BV (NL) | 2014-11-05 | — | — | EP | disclosed |
| US-8859629-B2 | Fused cyclooctyne compounds and their use in metal-free click reactions | SYNAFFIX B.V. (NL) | 2014-10-14 | — | — | US | disclosed |
| US-8859629-B2 | Fused cyclooctyne compounds and their use in metal-free click reactions | SYNAFFIX B.V. (NL) | 2014-10-14 | — | — | US | disclosed |
| EP-2599785-A1 | Novel methods for the synthesis and purification of oligomers | Agilent Technologies, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20130137763-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. | 2013-05-30 | — | — | US | disclosed |
| US-20130137861-A1 | NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS | AGILENT TECHNOLOGIES, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130137763-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | SYNAFFIX B.V. | 2013-05-30 | — | — | US | disclosed |
| US-20130137861-A1 | NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS | AGILENT TECHNOLOGIES, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| EP-2522369-A1 | Pretargeting kit, method and agents used therein | Koninklijke Philips Electronics N.V. (NL) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011136645-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITY NIJMEGEN (NL) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137861-A1 | NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS | RTCB, CACYBP, PHAX | RAB9A 4731/4885PPM1B 2032/4885PTPN1 2977/4885 |
| US-20130137763-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | MPI, SQLE, TACR3 | RAB9A 3302/4885PPM1B 4239/4885PTPN1 4258/4885 |
| US-20160214917-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | MPI, SQLE, TACR3 | RAB9A 3302/4885PPM1B 4239/4885PTPN1 4258/4885 |
| US-20150125892-A1 | FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS | MPI, SQLE, TACR3 | RAB9A 3302/4885PPM1B 4239/4885PTPN1 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.