Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 12/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002937 | 0.86 | SMYD3 (0.52) | SMYD3CRBNMGLLHSD11B1 | |
| SCHEMBL29899587 | 0.86 | SMYD3 (0.53) | SMYD3CRBNMGLLHSD11B1 | |
| SCHEMBL29899647 | 0.82 | CRBN (0.71) | SMYD3CRBN | |
| SCHEMBL23143574 | 0.82 | CRBN (0.71) | SMYD3CRBN | |
| SCHEMBL23374113 | 0.81 | SMYD3 (0.49) | SMYD3CRBNMGLLHSD11B1 | |
| SCHEMBL23175631 | 0.80 | SMYD3 (0.61) | SMYD3CRBNMGLLHSD11B1 | |
| SCHEMBL23143550 | 0.78 | SMYD3 (0.72) | SMYD3CRBN | |
| SCHEMBL29899597 | 0.78 | SMYD3 (0.72) | SMYD3CRBN | |
| SCHEMBL29899605 | 0.77 | SMYD3 (0.58) | SMYD3CRBN | |
| SCHEMBL23143511 | 0.77 | MGLL (0.56) | SMYD3CRBNMGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154518-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-15 | — | — | WO | disclosed |