Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.61 |
| ▸ | MTOR | P42345 | 8/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.56 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.52 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828786 | 0.86 | PIK3CA (0.57) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL13828796 | 0.86 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL13828878 | 0.84 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL13828589 | 0.81 | ALDH1A1 (0.52) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL13828614 | 0.79 | MTOR (0.56) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL13828677 | 0.79 | ALDH1A1 (0.43) | PIK3CAMTOR | |
| SCHEMBL13828679 | 0.79 | PIK3CA (0.57) | PIK3CAMTORPIK3CGFLT3CLK4 | |
| SCHEMBL13828820 | 0.78 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL13828794 | 0.77 | PIK3CA (0.54) | PIK3CAMTORPIK3CGPRKDC | |
| SCHEMBL13572313 | 0.76 | MTOR (0.62) | PIK3CAMTORPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9801888-B2 | Pyrimidine compounds as mTOR and PI3K inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2017-10-31 | — | — | US | disclosed |
| US-20160136176-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2016-05-19 | — | — | US | disclosed |
| US-9315491-B2 | Pyrimidine compounds as mTOR and PI3K inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2016-04-19 | — | — | US | disclosed |
| US-20140178360-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DCB-USA LLC (US) | 2014-06-26 | — | — | US | disclosed |
| US-20120288492-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DCB-USA LLC (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120288492-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885MTOR 1/4885PIK3CG 9/4885 |
| US-20160136176-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885MTOR 1/4885PIK3CG 9/4885 |
| US-20140178360-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885MTOR 1/4885PIK3CG 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.