Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439581 | 0.81 | NR3C2 (0.53) | RXFP1POLBSMN1; SMN2HPGDKMT2A | |
| SCHEMBL1384217 | 0.72 | NR3C2 (0.56) | SMN1; SMN2HPGDKMT2ANR3C2MCL1 | |
| SCHEMBL2441015 | 0.71 | NR3C2 (0.54) | POLBSMN1; SMN2KMT2ANR3C2ALB | |
| SCHEMBL1382118 | 0.71 | NR3C2 (0.56) | POLBKMT2ANR3C2MCL1ALB | |
| SCHEMBL1382211 | 0.69 | NR3C2 (0.62) | POLBKMT2AIRAK4NR3C2ALB | |
| SCHEMBL1378799 | 0.69 | NR3C2 (0.53) | RXFP1POLBSMN1; SMN2HPGDKMT2A | |
| SCHEMBL1380607 | 0.69 | NR3C2 (0.73) | POLBNR3C2ALBHTR1ASLC6A2 | |
| SCHEMBL6792646 | 0.69 | LMNA (0.47) | RXFP1POLBSMN1; SMN2ALBHTR1A | |
| SCHEMBL1382718 | 0.69 | NR3C2 (0.49) | POLBSMN1; SMN2HPGDKMT2ANR3C2 | |
| SCHEMBL1382455 | 0.68 | NR3C2 (0.51) | RXFP1POLBSMN1; SMN2NR3C2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4703649-B2 | — | — | 2011-06-15 | — | — | JP | claimed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |