Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.69 |
| ▸ | FLT3 | P36888 | 15/20 | 0.69 |
| ▸ | FLT1 | P17948 | 6/20 | 0.69 |
| ▸ | FLT4 | P35916 | 6/20 | 0.69 |
| ▸ | PLK4 | O00444 | 5/20 | 0.69 |
| ▸ | AURKA | O14965 | 5/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.69 |
| ▸ | PRKACA | P17612 | 5/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.69 |
| ▸ | MARK3 | P27448 | 5/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.69 |
| ▸ | STK3 | Q13188 | 5/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.69 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.69 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.69 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.69 |
| ▸ | CDK1 | P06493 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421009 | 0.90 | KDR (0.76) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL420903 | 0.88 | FLT3 (0.79) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27842257 | 0.83 | KDR (0.81) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL419765 | 0.82 | KDR (1.00) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL29968423 | 0.82 | KDR (0.71) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL16681039 | 0.82 | KDR (0.71) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL422239 | 0.81 | KDR (1.00) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27636395 | 0.81 | KDR (0.79) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL421605 | 0.81 | KDR (0.79) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27657314 | 0.81 | KDR (0.79) | KDRFLT3FLT1FLT4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4810427-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | claimed |