Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948710 | 0.68 | L3MBTL1 (0.50) | CYP1A2POLBPIK3CGADORA3ADORA1 | |
| SCHEMBL31506448 | 0.68 | GDA (0.55) | ADORA3MAPTBRAFPTK2 | |
| SCHEMBL750335 | 0.68 | GDA (0.55) | ADORA3MAPTBRAFPTK2 | |
| SCHEMBL11639841 | 0.67 | L3MBTL1 (0.41) | CYP1A2L3MBTL1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL30450893 | 0.67 | L3MBTL1 (0.41) | CYP1A2L3MBTL1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL25055275 | 0.66 | L3MBTL1 (0.40) | CYP1A2L3MBTL1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3299561 | 0.65 | POLB (0.62) | CYP1A2POLBADORA3ADORA1L3MBTL1 | |
| SCHEMBL9380860 | 0.65 | CYP1A2 (0.37) | CYP1A2POLBADORA3ADORA1L3MBTL1 | |
| SCHEMBL9380847 | 0.65 | CYP1A2 (0.40) | CYP1A2ACHEAPPPOLBADORA3 | |
| SCHEMBL19127706 | 0.65 | CYP3A4 (0.47) | CYP1A2L3MBTL1CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707487-B1 | RIBOSWITCHES | UNIV MANCHESTER (GB) | 2017-10-04 | — | — | EP | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| WO-2012153142-A2 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2012-11-15 | — | — | WO | disclosed |