Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.88 |
| ▸ | EDNRB | P24530 | 17/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | TSPO | P30536 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764866 | 0.96 | EDNRA (0.88) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL5764942 | 0.94 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL13747832 | 0.94 | EDNRA (0.84) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL1386375 | 0.94 | EDNRA (0.84) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL1384143 | 0.85 | EDNRA (0.85) | EDNRAEDNRB | |
| SCHEMBL1386124 | 0.82 | EDNRB (0.79) | EDNRAEDNRB | |
| SCHEMBL1386650 | 0.81 | EDNRB (0.79) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL1384775 | 0.81 | EDNRB (0.70) | EDNRAEDNRB | |
| SCHEMBL1386269 | 0.80 | EDNRB (0.76) | EDNRAEDNRB | |
| SCHEMBL1386495 | 0.79 | EDNRB (0.75) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4832706-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| EP-1309564-B1 | ARYLETHENE-SULFONAMIDES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-14 | — | — | EP | claimed |