Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | TACR1 | P25103 | 1/20 | 0.56 |
| ▸ | TACR3 | P29371 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480383 | 1.00 | CYP2C19 (0.69) | CYP2C19TACR1TACR3ALDH1A1KMT2A | |
| SCHEMBL5742971 | 0.90 | CYP2C19 (0.65) | CYP2C19ALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL5742979 | 0.90 | CYP2C19 (0.65) | CYP2C19ALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2473764 | 0.84 | ALDH1A1 (0.52) | CYP2C19ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL2473759 | 0.84 | ALDH1A1 (0.52) | CYP2C19ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL6039757 | 0.84 | ALDH1A1 (0.52) | CYP2C19ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL15245316 | 0.83 | TACR1 (0.54) | CYP2C19TACR1TACR3ALDH1A1KMT2A | |
| SCHEMBL21641795 | 0.82 | DPP4 (0.73) | CYP2C19KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6438364 | 0.82 | DPP4 (0.73) | CYP2C19KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6438370 | 0.82 | DPP4 (0.73) | CYP2C19KMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| US-9085555-B2 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2015-07-21 | — | — | US | disclosed |
| US-20120295884-A1 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295884-A1 | Complement pathway modulators and uses thereof | C5, C3AR1, C9 | CYP2C19 188/4885TACR1 165/4885TACR3 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.