Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.66 |
| ▸ | FOS | P01100 | 1/20 | 0.66 |
| ▸ | JUN | P05412 | 1/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934305 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL27497698 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL29244511 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL16410054 | 0.89 | MAOB (0.57) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL3580365 | 0.86 | FOS (0.79) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL3580362 | 0.86 | FOS (0.79) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL29822711 | 0.86 | FOS (0.79) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL80786 | 0.85 | FOS (0.72) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL2632249 | 0.85 | MAOB (0.68) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL80787 | 0.85 | FOS (0.72) | MAOBFOSJUNBCHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777712-B | Tetrahydroisoquinoliderivs derivs and its application | 沈阳药科大学 | 2018-05-22 | — | — | CN | claimed |
| CN-105777712-A | Tetrahydroisoquinoline derivative and application thereof | 沈阳药科大学 | 2016-07-20 | — | — | CN | claimed |
| JP-4828407-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| EP-1594869-A2 | 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF | Targacept, Inc. (US) | 2005-11-16 | — | — | EP | claimed |
| WO-2004076449-A2 | 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF | TARGACEPT, INC. (US) | 2004-09-10 | — | — | WO | claimed |
| CN-116768792-B | Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof | 浙江工业大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-113462278-B | Varnish composition, method for producing polyimide resin, and additive | 东京应化工业株式会社 | 2024-06-07 | — | — | CN | disclosed |
| CN-116768792-A | Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof | 浙江工业大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-110256274-B | Method for preparing N-methyl-N-phenyl-2, 3-dibromo-3-substituted phenylpropionamide compound | 安徽理工大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-105777712-B | Tetrahydroisoquinoliderivs derivs and its application | 沈阳药科大学 | 2018-05-22 | — | — | CN | disclosed |
| CN-105777712-A | Tetrahydroisoquinoline derivative and application thereof | 沈阳药科大学 | 2016-07-20 | — | — | CN | disclosed |
| EP-2968308-A1 | METHODS OF TREATING B2-BRADYKININ RECEPTOR MEDIATED ANGIOEDEMA | Shire Human Genetic Therapies, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014159637-A1 | METHODS OF TREATING B2-BRADYKININ RECEPTOR MEDIATED ANGIOEDEMA | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-1725240-A4 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-03-25 | — | — | EP | disclosed |
| EP-1725240-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-11-29 | — | — | EP | disclosed |
| EP-1594869-A2 | 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF | Targacept, Inc. (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2005094834-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-10-13 | — | — | WO | disclosed |
| WO-2004076449-A2 | 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF | TARGACEPT, INC. (US) | 2004-09-10 | — | — | WO | disclosed |