Sugi Predict

Sugi Predict / Targets / FOS

FOS

Protein c-Fos · P01100 · FOS on Sugi Atlas →

11,965 patent compounds predicted against FOS, 9,208 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL336184 SCHEMBL336184 0.69 8/20
SCHEMBL336181 SCHEMBL336181 0.53 7/20
SCHEMBL541611 SCHEMBL541611 0.45 7/20
SCHEMBL131646 SCHEMBL131646 0.58 5/20
SCHEMBL423492 SCHEMBL423492 0.60 4/20
SCHEMBL653649 SCHEMBL653649 0.59 4/20
SCHEMBL574247 SCHEMBL574247 0.54 4/20
SCHEMBL573798 SCHEMBL573798 0.53 4/20
SCHEMBL1627061 SCHEMBL1627061 0.53 4/20
SCHEMBL336505 SCHEMBL336505 0.47 4/20
SCHEMBL541944 SCHEMBL541944 0.45 4/20
SCHEMBL1549336 SCHEMBL1549336 0.55 3/20
SCHEMBL346837 SCHEMBL346837 0.49 3/20
SCHEMBL1549456 SCHEMBL1549456 0.48 3/20
SCHEMBL183644 SCHEMBL183644 0.43 3/20
SCHEMBL125364 SCHEMBL125364 0.42 3/20
SCHEMBL1592571 SCHEMBL1592571 0.32 3/20
Masoprocol Masoprocol (SCHEMBL3818) 1.00 2/20
Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid (SCHEMBL135976) 1.00 2/20
SCHEMBL608506 SCHEMBL608506 1.00 2/20

Clinical trials — most relevant to FOS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery. PHASE4COMPLETED
Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach PHASE4COMPLETED
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES PHASE3COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3COMPLETED
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving PHASE2COMPLETED
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H... PHASE2COMPLETED
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome PHASE2COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Metformin for Fibromyalgia Symptoms (INFORM Trial) PHASE2RECRUITING
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus PHASE1COMPLETED
Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents PHASE1COMPLETED
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals EARLY_PHASE1COMPLETED
Bone Resorption, Osteoclastogenesis and Adalimumab nanCOMPLETED
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis nanCOMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy. nanUNKNOWN
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients nanRECRUITING
Effect of Gabapentin on GABA Concentration and Emotional Processing nanCOMPLETED
Inflammatory Markers as Predictors of the Efficacy of Electroconvulsive Therapy (ECT) in Major Depression Patients nanCOMPLETED
MMP Polymorphisms and Acute Coronary Syndromes nanCOMPLETED
Neuroimaging Memories of Fear and Safety in the Human Brain nanUNKNOWN
Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula nanRECRUITING
IGF and Other Neurotrophic Factors in Patients With Dementia nanCOMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection. nanCOMPLETED
Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis nanCOMPLETED
Satiety Evaluation of Mature Okra Flour-incorporated Biscuit nanRECRUITING
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
Prefrontal Oscillations in Social Anxiety Disorder (POSAD) nanACTIVE_NOT_RECRUITING
Pulsed Electro Magnetic Fields (PEMF) in Depression nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FOS binder may also engage these)

ProteinNameSimilarity
O88479 — 1.000 O88479 →
P12841 — 1.000 P12841 →
O97930 — 1.000 O97930 →
Q56TN0 — 1.000 Q56TN0 →
Q8HZP6 — 1.000 Q8HZP6 →
Q9Z2Q8 — 1.000 Q9Z2Q8 →
O77628 — 1.000 O77628 →
Q56TT7 — 1.000 Q56TT7 →
P01101 — 0.999 P01101 →
P23050 — 0.997 P23050 →
D3ZLB7 — 0.997 D3ZLB7 →
FOSB Protein FosB 0.995 landscape →
P29176 — 0.994 P29176 →
P13346 — 0.994 P13346 →
P01102 — 0.993 P01102 →
P53450 — 0.993 P53450 →
Q91496 — 0.992 Q91496 →
Q9TUB3 — 0.990 Q9TUB3 →
P11939 — 0.990 P11939 →
P79702 — 0.989 P79702 →
P48755 — 0.988 P48755 →
P24793 — 0.987 P24793 →
P10158 — 0.986 P10158 →
P15407 — 0.985 P15407 →
Q9Z125 — 0.985 Q9Z125 →
O02761 — 0.983 O02761 →
A2VD01 — 0.983 A2VD01 →
P18625 — 0.983 P18625 →
Q66HA2 — 0.982 Q66HA2 →
Q9PSI9 — 0.981 Q9PSI9 →