Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 8/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13729449 | 0.84 | IL2 (0.51) | IL2ABL1SIRT3TDP1 | |
| SCHEMBL13727779 | 0.84 | IL2 (0.51) | IL2ABL1SIRT3TDP1 | |
| SCHEMBL13730310 | 0.84 | IL2 (0.47) | IL2ABL1NPC1RAB9ATP53 | |
| SCHEMBL13838310 | 0.81 | IL2 (0.54) | IL2ABL1 | |
| SCHEMBL15803768 | 0.80 | IL2 (0.43) | IL2ABL1NPC1RAB9A | |
| SCHEMBL15803787 | 0.79 | IL2 (0.43) | IL2ABL1SIRT3TDP1CSNK1D | |
| SCHEMBL13729037 | 0.79 | IL2 (0.47) | IL2ABL1NPC1RAB9ATP53 | |
| SCHEMBL15803788 | 0.78 | IL2 (0.42) | IL2ABL1SIRT3TDP1CSNK1D | |
| SCHEMBL18671439 | 0.78 | IL2 (0.42) | IL2ABL1SIRT3TDP1CSNK1D | |
| SCHEMBL13727394 | 0.78 | IL2 (0.46) | IL2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151355-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2012-11-08 | — | — | WO | disclosed |