Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13839354 | 0.93 | LRRK2 (0.40) | LRRK2ITKFGFR1FLT1NTRK1 | |
| SCHEMBL12318030 | 0.78 | LRRK2 (0.50) | LRRK2ITKFGFR1FLT1CLK2 | |
| SCHEMBL12619743 | 0.78 | AXL (0.44) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13839355 | 0.77 | TDP1 (0.36) | LRRK2FGFR1KDM4EALDH1A1MEN1 | |
| SCHEMBL12269735 | 0.75 | TDP1 (0.46) | LRRK2ITKKDM4EALDH1A1TDP1 | |
| SCHEMBL12318033 | 0.73 | LRRK2 (0.51) | LRRK2ITKFGFR1FLT1NTRK1 | |
| SCHEMBL12269662 | 0.68 | TDP1 (0.38) | ITKDYRK1AKDM4EALDH1A1KMT2A | |
| SCHEMBL5945712 | 0.66 | PRKAG1 (0.68) | ITKFGFR1FLT1JAK2KDM4E | |
| SCHEMBL5945683 | 0.65 | MEN1 (0.58) | LRRK2ITKDYRK1AKDM4EALDH1A1 | |
| SCHEMBL16025888 | 0.63 | LRRK2 (0.63) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BRAF, MAP3K1, MAP3K3 | LRRK2 391/4885ITK 480/4885FGFR1 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.