Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13841905 | 0.89 | MAPT (0.46) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10113454 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10113727 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10133367 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10113622 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10115381 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10113352 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10115047 | 0.88 | MAPT (0.48) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL13972710 | 0.84 | MAPT (0.49) | MAPTKDM4EGAAALDH1A1CNR1 | |
| SCHEMBL13972909 | 0.82 | MAPT (0.56) | MAPTKDM4EGAAALDH1A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534892-B2 | Sulfonamide compound | SHIONOGI & CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-7534892-B2 | Sulfonamide compound | SHIONOGI & CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-20070287710-A1 | Piperidinediyl-containing sulfonamide; NPY Y5 receptor antagonist activity; antiobesity agent or anorectic agent | SHIONOGI & CO., LTD. (JP) | 2007-12-13 | — | — | US | disclosed |
| US-20070287710-A1 | Piperidinediyl-containing sulfonamide; NPY Y5 receptor antagonist activity; antiobesity agent or anorectic agent | SHIONOGI & CO., LTD. (JP) | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287710-A1 | Piperidinediyl-containing sulfonamide; NPY Y5 receptor antagonist activity; antiobesity agent or anorectic agent | NPY5R, NPY1R, NPY2R | MAPT 4654/4885KDM4E 704/4885GAA 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.