Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.59 |
| ▸ | JAK3 | P52333 | 15/20 | 0.59 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13842341 | 0.90 | JAK2 (0.72) | JAK2JAK3CDK9 | |
| SCHEMBL2938519 | 0.84 | JAK2 (0.79) | JAK2JAK3ITGB2ICAM1ITGAL | |
| SCHEMBL13842340 | 0.80 | JAK2 (0.85) | JAK2JAK3ITGB2ICAM1ITGAL | |
| SCHEMBL13842339 | 0.79 | JAK2 (0.70) | JAK2JAK3 | |
| SCHEMBL13842587 | 0.77 | JAK2 (0.70) | JAK2JAK3 | |
| SCHEMBL13842328 | 0.73 | JAK2 (1.00) | JAK2JAK3ITGB2ICAM1ITGAL | |
| SCHEMBL13842332 | 0.72 | JAK2 (0.71) | JAK2JAK3 | |
| SCHEMBL13842331 | 0.70 | JAK2 (0.71) | JAK2JAK3 | |
| SCHEMBL13842329 | 0.69 | JAK2 (0.68) | JAK2JAK3 | |
| SCHEMBL13842330 | 0.69 | JAK2 (0.70) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |