Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.79 |
| ▸ | JAK3 | P52333 | 19/20 | 0.79 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13842341 | 0.90 | JAK2 (0.72) | JAK2JAK3 | |
| SCHEMBL13842332 | 0.89 | JAK2 (0.71) | JAK2JAK3 | |
| SCHEMBL13842328 | 0.88 | JAK2 (1.00) | JAK2JAK3ITGB2ICAM1ITGAL | |
| SCHEMBL13842331 | 0.87 | JAK2 (0.71) | JAK2JAK3 | |
| SCHEMBL13842329 | 0.86 | JAK2 (0.68) | JAK2JAK3 | |
| SCHEMBL13842330 | 0.85 | JAK2 (0.70) | JAK2JAK3 | |
| SCHEMBL13178258 | 0.84 | JAK2 (0.67) | JAK2JAK3 | |
| SCHEMBL13842589 | 0.84 | JAK2 (0.59) | JAK2JAK3ITGB2ICAM1ITGAL | |
| SCHEMBL13842260 | 0.82 | JAK2 (0.67) | JAK2JAK3 | |
| SCHEMBL13842340 | 0.80 | JAK2 (0.85) | JAK2JAK3ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812440-B1 | PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-09-22 | — | — | EP | disclosed |
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1812440-A1 | PYRAZOLOÝ1,5-a¨PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060135537-A1 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2006-06-22 | — | — | US | disclosed |
| WO-2006052913-A1 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135537-A1 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | MAP3K5, MAP3K20, MAP3K1 | JAK2 160/4885JAK3 188/4885ITGB2 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.