Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 2/20 | 0.35 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14099272 | 0.76 | SCN1A (0.40) | FFAR2SCN1ASCN2ASCN3ATSHR | |
| SCHEMBL4722623 | 0.75 | SCN1A (0.43) | FFAR2FBP1HTR7SCN1ASCN2A | |
| SCHEMBL14099264 | 0.74 | SCN1A (0.42) | FFAR2FBP1HTR7SCN1ASCN2A | |
| SCHEMBL173416 | 0.74 | — | — | |
| SCHEMBL19997269 | 0.72 | FFAR2 (0.37) | FFAR2FBP1HTR7SCN1ASCN2A | |
| SCHEMBL2226558 | 0.72 | — | — | |
| SCHEMBL14099274 | 0.70 | MEN1 (0.44) | ALDH1A1TSHRHSD17B10LMNA | |
| SCHEMBL4720415 | 0.69 | SCN1A (0.42) | FFAR2FBP1HTR7SCN1ASCN2A | |
| SCHEMBL13844014 | 0.69 | TSHR (0.43) | FBP1TSHR | |
| SCHEMBL12873564 | 0.69 | TAAR1 (0.36) | TSHRLATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528163-B2 | N,N-Dibutyl-2-[3-(2,2-dimethylpropanoyl)-6-methoxy-1H-indazol-1-yl]acetamide; potassium channel blocker; eye neuroprotectant; hypotensive agent; glaucoma, intraoccular pressure in the eye | MERCK & CO. INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-7414067-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2008-08-19 | — | — | US | disclosed |