Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12269673 | 0.91 | ROCK2 (0.39) | ATMHDAC6ROCK2GSK3BDYRK1A | |
| SCHEMBL12269784 | 0.81 | AKT1 (0.40) | MAPK1 | |
| SCHEMBL12269661 | 0.76 | MAP2K4 (0.42) | DYRK1AMEN1KMT2A | |
| SCHEMBL12317853 | 0.75 | ROCK2 (0.43) | ROCK2GSK3BDYRK1AMAPK1ROCK1 | |
| SCHEMBL12269662 | 0.73 | TDP1 (0.38) | DYRK1AKMT2AMAPK1 | |
| SCHEMBL12269788 | 0.66 | GSK3B (0.45) | GSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL12269795 | 0.66 | ATM (0.49) | ATMMEN1KMT2A | |
| SCHEMBL12269971 | 0.66 | HPGD (0.45) | ROCK2MAPK1 | |
| SCHEMBL12269677 | 0.66 | KDM4E (0.48) | ROCK2MEN1KMT2AMAPK1ROCK1 | |
| SCHEMBL12269735 | 0.66 | TDP1 (0.46) | ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009059030-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-07 | — | — | WO | disclosed |