Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833476 | 0.96 | EGFR (0.39) | KITRETKDREGFRTSHR | |
| SCHEMBL2831983 | 0.95 | KIT (0.47) | KITRETKDREGFRPDGFRB | |
| Hydrochloric Acid SCHEMBL2833456 | 0.94 | KIT (0.46) | KITRETKDREGFRALDH1A1 | |
| SCHEMBL2837582 | 0.89 | EGFR (0.42) | KITRETKDRENPP1EGFR | |
| SCHEMBL16507592 | 0.86 | EGFR (0.53) | KITEGFRALDH1A1ERBB2ACHE | |
| SCHEMBL2836761 | 0.83 | ABCG2 (0.43) | EGFRPDGFRBALDH1A1LMNAHPGD | |
| SCHEMBL13090429 | 0.81 | ERBB2 (0.43) | RETKDREGFRPDGFRBALDH1A1 | |
| SCHEMBL2834365 | 0.81 | ABCG2 (0.51) | EGFRPDGFRBALDH1A1ERBB2ACHE | |
| SCHEMBL2836110 | 0.77 | P2RX7 (0.44) | ENPP1EGFRERBB2P2RX7FBP1 | |
| SCHEMBL2830929 | 0.76 | ABCG2 (0.44) | ENPP1EGFRPDGFRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009057139-A2 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-05-07 | — | — | WO | disclosed |