Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 17/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844732 | 0.86 | LTA4H (0.46) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844739 | 0.86 | LTA4H (0.42) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844688 | 0.84 | LTA4H (0.46) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844610 | 0.84 | LTA4H (0.44) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844686 | 0.84 | LTA4H (0.49) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844619 | 0.82 | LTA4H (0.45) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844695 | 0.81 | LTA4H (0.44) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844811 | 0.80 | LTA4H (0.43) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844634 | 0.79 | LTA4H (0.47) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13844734 | 0.78 | LTA4H (0.52) | LTA4HKCNH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058347-A1 | ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |