Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844619 | 0.92 | LTA4H (0.45) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844638 | 0.92 | LTA4H (0.42) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844809 | 0.89 | LTA4H (0.52) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844734 | 0.89 | LTA4H (0.52) | LTA4HEPHX2KCNH2 | |
| SCHEMBL13844691 | 0.88 | LTA4H (0.49) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844807 | 0.86 | LTA4H (0.47) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844634 | 0.86 | LTA4H (0.47) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844609 | 0.81 | LTA4H (0.46) | LTA4HEPHX2KCNH2 | |
| SCHEMBL13844603 | 0.80 | LTA4H (0.45) | LTA4HEPHX2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL13844731 | 0.80 | LTA4H (0.45) | LTA4HEPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058347-A1 | ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |