Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368116 | 0.84 | KMT2A (0.42) | SMN1; SMN2POLBTDP1SIGMAR1GAA | |
| SCHEMBL1923196 | 0.80 | HPGD (0.48) | SMN1; SMN2PTGDR2TP53GAAHTT | |
| SCHEMBL15492140 | 0.80 | PTGS2 (0.45) | SMN1; SMN2POLBPTGDR2TP53GAA | |
| SCHEMBL2367523 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBPTGDR2TP53GAA | |
| SCHEMBL435010 | 0.78 | KDM4E (0.54) | POLBGAATSHRMAPK1KMT2A | |
| SCHEMBL12292517 | 0.77 | POLB (0.40) | SMN1; SMN2POLBPTGDR2TP53GAA | |
| SCHEMBL1923628 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBPTGDR2TP53GAA | |
| SCHEMBL21523724 | 0.75 | GAA (0.72) | SMN1; SMN2POLBPTGDR2TP53GAA | |
| SCHEMBL3655900 | 0.75 | POLB (0.57) | SMN1; SMN2POLBPTGDR2TDP1SIGMAR1 | |
| SCHEMBL3788811 | 0.74 | KLKB1 (0.48) | SMN1; SMN2POLBTP53GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056556-A1 | SUBSTITUTE 1, 6-NAPHTHYRIDINES FOR USE AS SCD INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |