Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | F10 | P00742 | 6/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284385 | 1.00 | POLB (0.56) | POLBF10KLKB1CFDCCR1 | |
| SCHEMBL13316240 | 0.93 | POLB (0.51) | POLBF10KLKB1CFDCCR1 | |
| SCHEMBL3583539 | 0.93 | POLB (0.52) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3583002 | 0.88 | POLB (0.55) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3580388 | 0.85 | POLB (0.55) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3581948 | 0.84 | POLB (0.53) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3582631 | 0.83 | POLB (0.55) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3588453 | 0.82 | POLB (0.52) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3580372 | 0.82 | POLB (0.54) | POLBF10KLKB1CCR1MEN1 | |
| SCHEMBL3591636 | 0.82 | POLB (0.55) | POLBF10KLKB1CCR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4800969-B2 | — | — | 2011-10-26 | — | — | JP | claimed |
| EP-1697318-B1 | PROLINYLARYLACETAMIDES | MERCK PATENT GMBH (DE) | 2008-08-27 | — | — | EP | claimed |
| EP-1697318-A1 | PROLINYLARYLACETAMIDES | MERCK PATENT GmbH (DE) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058817-A1 | PROLINYLARYLACETAMIDES | MERCK PATENT GMBH (DE) | 2005-06-30 | — | — | WO | claimed |
| EP-1697318-B1 | PROLINYLARYLACETAMIDES | MERCK PATENT GMBH (DE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1697318-A1 | PROLINYLARYLACETAMIDES | MERCK PATENT GmbH (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058817-A1 | PROLINYLARYLACETAMIDES | MERCK PATENT GMBH (DE) | 2005-06-30 | — | — | WO | disclosed |