Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.35 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.35 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.35 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.35 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.35 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.35 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284385 | 0.93 | POLB (0.56) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL1384512 | 0.93 | POLB (0.56) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL13316240 | 0.91 | POLB (0.51) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL3583002 | 0.89 | POLB (0.55) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL3581948 | 0.84 | POLB (0.53) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL3583546 | 0.84 | POLB (0.52) | POLBKLKB1F10MEN1KMT2A | |
| SCHEMBL3583537 | 0.84 | POLB (0.52) | POLBKLKB1F10MEN1KMT2A | |
| SCHEMBL3588453 | 0.83 | POLB (0.52) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL3591636 | 0.83 | POLB (0.55) | POLBKLKB1F10CCR1MEN1 | |
| SCHEMBL3580417 | 0.83 | POLB (0.55) | POLBKLKB1F10CCR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732481-B2 | Prolinylarylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-06-08 | — | — | US | claimed |
| EP-1697318-B1 | PROLINYLARYLACETAMIDES | MERCK PATENT GMBH (DE) | 2008-08-27 | — | — | EP | claimed |
| US-20070185189-A1 | Prolinylarylacetamides | MERCK PATENT GMBH (DE) | 2007-08-09 | — | — | US | claimed |
| US-7732481-B2 | Prolinylarylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-06-08 | — | — | US | disclosed |
| US-20070185189-A1 | Prolinylarylacetamides | MERCK PATENT GMBH (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185189-A1 | Prolinylarylacetamides | F12, F11, F2 | POLB 3435/4885KLKB1 1086/4885F10 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.