Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.36 |
| ▸ | JAK3 | P52333 | 10/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | PRKCG | P05129 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13608152 | 0.84 | KDM1A (0.40) | JAK2JAK3JAK1HTR2AHTR2C | |
| SCHEMBL13608193 | 0.73 | JAK2 (0.41) | JAK2JAK3JAK1FGFR1SRC | |
| SCHEMBL13845256 | 0.69 | HRH4 (0.38) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL12371710 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL12371773 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL12371742 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL12371733 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL12371745 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL13608449 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1MARK3TYK2 | |
| SCHEMBL13608444 | 0.64 | JAK2 (0.44) | JAK2JAK3JAK1TYK2USP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |