Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13608437 | 0.83 | JAK2 (0.43) | JAK2JAK3JAK1TYK2MERTK | |
| SCHEMBL13608390 | 0.83 | JAK2 (0.43) | JAK2JAK3JAK1TYK2MERTK | |
| SCHEMBL13845198 | 0.78 | JAK2 (0.41) | JAK2JAK3JAK1TYK2CYP2D6 | |
| SCHEMBL13608378 | 0.77 | JAK2 (0.44) | HRH4JAK2JAK3JAK1TYK2 | |
| SCHEMBL13608308 | 0.77 | JAK2 (0.44) | HRH4JAK2JAK3JAK1TYK2 | |
| SCHEMBL13608441 | 0.74 | JAK2 (0.44) | JAK2JAK3JAK1TYK2CYP2D6 | |
| SCHEMBL13608426 | 0.72 | JAK2 (0.42) | JAK2JAK3JAK1TYK2BRD4 | |
| SCHEMBL13608448 | 0.72 | JAK2 (0.42) | JAK2JAK3JAK1TYK2BRD4 | |
| SCHEMBL13845148 | 0.69 | HRH3 (0.38) | HRH4HRH3KMT2AOPRM1MERTK | |
| SCHEMBL13845152 | 0.69 | JAK2 (0.36) | JAK2JAK3JAK1TYK2USP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |