Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Drospirenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 12/20 | 1.00 |
| ▸ | AR | P10275 | 11/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Drospirenone SCHEMBL13971411 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL13460142 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL18077735 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL153317 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL14227067 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL13015156 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL13356035 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL18717263 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL13355946 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA | |
| Drospirenone SCHEMBL22171517 | 1.00 | PGR (1.00) | PGRARNR3C1CHRM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009059765-A2 | PROCESS FOR THE PREPARATION OF DROSPIRENONE | CHORISIS S.R.L. (IT) | 2009-05-14 | — | — | WO | disclosed |