Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.71 |
| ▸ | FLT3 | P36888 | 14/20 | 0.71 |
| ▸ | KIT | P10721 | 13/20 | 0.68 |
| ▸ | CSF1R | P07333 | 7/20 | 0.68 |
| ▸ | FLT1 | P17948 | 7/20 | 0.68 |
| ▸ | FLT4 | P35916 | 7/20 | 0.68 |
| ▸ | LCK | P06239 | 6/20 | 0.68 |
| ▸ | LYN | P07948 | 6/20 | 0.68 |
| ▸ | BLK | P51451 | 6/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.68 |
| ▸ | SRC | P12931 | 3/20 | 0.68 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | MET | P08581 | 3/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.68 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.68 |
| ▸ | FRK | P42685 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424307 | 0.92 | KIT (0.81) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL422432 | 0.88 | KDR (0.82) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL424772 | 0.87 | KDR (0.84) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL425683 | 0.84 | KDR (0.79) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL423300 | 0.83 | KDR (1.00) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL420484 | 0.83 | KDR (0.74) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL421021 | 0.82 | KDR (0.80) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL422705 | 0.82 | KDR (0.79) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL1703583 | 0.81 | KIT (1.00) | KDRFLT3KITCSF1RFLT1 | |
| SCHEMBL419771 | 0.81 | KDR (1.00) | KDRFLT3KITCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4810427-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | claimed |