Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 11/20 | 0.81 |
| ▸ | FLT1 | P17948 | 9/20 | 0.81 |
| ▸ | CSF1R | P07333 | 8/20 | 0.81 |
| ▸ | FLT4 | P35916 | 6/20 | 0.81 |
| ▸ | LCK | P06239 | 4/20 | 0.81 |
| ▸ | LYN | P07948 | 4/20 | 0.81 |
| ▸ | BLK | P51451 | 4/20 | 0.81 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.81 |
| ▸ | FYN | P06241 | 3/20 | 0.81 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.81 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.81 |
| ▸ | CLK2 | P49760 | 3/20 | 0.81 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.81 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.81 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.81 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.81 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.81 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.81 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.81 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384538 | 0.92 | KDR (0.71) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL1703583 | 0.90 | KIT (1.00) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL425683 | 0.87 | KDR (0.79) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL422432 | 0.86 | KDR (0.82) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL423300 | 0.86 | KDR (1.00) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL1703605 | 0.86 | KDR (1.00) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL422705 | 0.85 | KDR (0.79) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL421021 | 0.85 | KDR (0.80) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL424772 | 0.83 | KDR (0.84) | KITFLT1CSF1RFLT4LCK | |
| SCHEMBL424857 | 0.83 | KDR (0.76) | KITFLT1CSF1RFLT4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245015-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2013-09-19 | — | — | US | claimed |
| US-8063091-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-22 | — | — | US | claimed |
| EP-1638941-B1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LAB (US) | 2010-06-02 | — | — | EP | claimed |
| US-20090286784-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-11-19 | — | — | US | claimed |
| US-20080076767-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC. | 2008-03-27 | — | — | US | claimed |
| US-7297709-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-11-20 | — | — | US | claimed |
| US-20050020603-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. | 2005-01-27 | — | — | US | claimed |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | claimed |
| US-8940778-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8642776-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130245015-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2013-09-19 | — | — | US | disclosed |
| US-20130030189-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8299243-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. (US) | 2012-10-30 | — | — | US | disclosed |
| EP-2246333-B1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2012-10-24 | — | — | EP | disclosed |
| US-20080076767-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC. | 2008-03-27 | — | — | US | disclosed |
| US-7297709-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-11-20 | — | — | US | disclosed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050020603-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. | 2005-01-27 | — | — | US | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245015-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KIT 361/4885FLT1 661/4885CSF1R 1113/4885 |
| US-20080076767-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KIT 361/4885FLT1 661/4885CSF1R 1113/4885 |
| US-20050020603-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABL1, BLK, BTK | KIT 361/4885FLT1 661/4885CSF1R 1113/4885 |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABL1, MAP3K19, MAP3K1 | KIT 238/4885FLT1 512/4885CSF1R 1006/4885 |
| US-20090286784-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KIT 361/4885FLT1 661/4885CSF1R 1113/4885 |
| US-20130030189-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KIT 361/4885FLT1 661/4885CSF1R 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.