Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954831 | 0.95 | AURKA (0.51) | AURKAAURKBFLT3CHEK1CCNA2 | |
| SCHEMBL8241005 | 0.80 | AURKA (0.64) | AURKAAURKBFLT3AXLIRAK4 | |
| SCHEMBL8240135 | 0.77 | AURKA (0.58) | AURKAAURKBFLT3AXLTTK | |
| SCHEMBL8241241 | 0.77 | AURKA (0.90) | AURKAAURKBFLT3CHEK1CCNA2 | |
| SCHEMBL14507668 | 0.77 | AURKB (0.65) | AURKAAURKBFLT3IRAK4CHEK1 | |
| SCHEMBL13954585 | 0.76 | AURKA (0.55) | AURKAAURKBFLT3CHEK1TTK | |
| SCHEMBL13954830 | 0.75 | AURKB (0.47) | AURKAAURKBFLT3TTK | |
| SCHEMBL13954586 | 0.75 | AURKB (0.49) | AURKAAURKBFLT3CHEK1TTK | |
| SCHEMBL8240997 | 0.74 | AURKB (0.57) | AURKAAURKBIRAK4TTKIRAK1 | |
| SCHEMBL8246210 | 0.74 | AURKA (0.55) | AURKAAURKBFLT3AXLTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061781-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |