Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 13/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845492 | 0.95 | AURKA (0.57) | AURKAAURKBFLT3CHEK1CCNA2 | |
| SCHEMBL13954863 | 0.79 | CHEK1 (0.45) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL8247571 | 0.78 | AURKA (0.58) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL13954586 | 0.78 | AURKB (0.49) | AURKAAURKBFLT3CHEK1CCNA2 | |
| SCHEMBL8241235 | 0.77 | AURKA (0.81) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL8241222 | 0.77 | AURKA (0.58) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL8241005 | 0.77 | AURKA (0.64) | AURKAAURKBFLT3CHEK1 | |
| SCHEMBL8240948 | 0.76 | AURKA (0.56) | AURKAAURKBCHEK1CCNA2CDK2 | |
| SCHEMBL8240135 | 0.76 | AURKA (0.58) | AURKAAURKBFLT3 | |
| SCHEMBL8246210 | 0.75 | AURKA (0.55) | AURKAAURKBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |