Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.48 |
| ▸ | TTK | P33981 | 11/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240135 | 0.77 | AURKA (0.58) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8246210 | 0.74 | AURKA (0.55) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8240570 | 0.74 | AURKA (0.63) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954585 | 0.74 | AURKA (0.55) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8240563 | 0.72 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8241005 | 0.72 | AURKA (0.64) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536836 | 0.72 | AURKA (0.55) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8240574 | 0.71 | AURKA (0.59) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8239708 | 0.71 | AURKA (0.62) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8239744 | 0.70 | AURKA (0.64) | AURKAAURKBTTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061781-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |