Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 5/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241658 | 0.81 | AURKA (0.62) | AURKAAURKBCHEK1TTKPKM | |
| SCHEMBL8239869 | 0.79 | AURKA (0.68) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL8240285 | 0.75 | AURKA (0.56) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL13154745 | 0.75 | AURKA (0.56) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL8240802 | 0.74 | AURKA (0.66) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL8240290 | 0.73 | AURKA (0.67) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL8246421 | 0.72 | AURKA (0.63) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL8239874 | 0.72 | AURKA (0.69) | AURKAAURKBCHEK1TTKFLT3 | |
| SCHEMBL13845549 | 0.72 | AURKA (0.49) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8247201 | 0.72 | AURKA (0.68) | AURKAAURKBCHEK1TTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |