SCHEMBL13845563

SCHEMBL13845563

Cn1cc(NC(=O)CCNC(=O)OC(C)(C)C)cc1C(=O)Nc1cn(C)c(C(=O)O)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.49
HDAC2 Q92769 2/20 0.49
HDAC8 Q9BY41 2/20 0.49
TOP1 P11387 2/20 0.42
SUV39H2 Q9H5I1 2/20 0.40
HRAS P01112 1/20 0.40
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
KDM4E B2RXH2 2/20 0.39
POLB P06746 2/20 0.39
MAPT P10636 1/20 0.39
HIF1A Q16665 1/20 0.39
ERBB2 P04626 3/20 0.39
ABL1 P00519 1/20 0.38
PDGFRB P09619 1/20 0.38
SRC P12931 1/20 0.38
PDGFRA P16234 1/20 0.38
MAPK14 Q16539 1/20 0.38
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23744959 0.93 HDAC1 (0.55) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL23745098 0.93 HDAC1 (0.55) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL31469836 0.92 HDAC1 (0.51) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL30125562 0.92 HDAC1 (0.51) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL13845730 0.91 HDAC1 (0.55) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL4100605 0.89 HDAC1 (0.46) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL23745126 0.89 HDAC1 (0.55) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL23745121 0.89 HDAC1 (0.55) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL13845685 0.89 HDAC1 (0.53) HDAC1HDAC2HDAC8TOP1SUV39H2
SCHEMBL13845637 0.87 HDAC1 (0.42) HDAC1HDAC2HDAC8SUV39H2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025122764-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES Design Therapeutics, Inc. (US) 2025-06-12 WO disclosed
EP-4539839-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES Design Therapeutics, Inc. (US) 2025-04-23 EP disclosed
WO-2025076181-A1 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2025-04-10 WO disclosed
EP-4504339-A2 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2025-02-12 EP disclosed
EP-4384506-A1 PROCESS FOR POLYAMIDE SYNTHESIS Design Therapeutics, Inc. (US) 2024-06-19 EP disclosed
WO-2023244678-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES Design Therapeutics, Inc. (US) 2023-12-21 WO disclosed
EP-4259133-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 Design Therapeutics, Inc. (US) 2023-10-18 EP disclosed
WO-2023192642-A2 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2023-10-05 WO disclosed
WO-2023192642-A2 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2023-10-05 WO disclosed
WO-2023014793-A1 PROCESS FOR POLYAMIDE SYNTHESIS Design Therapeutics, Inc. (US) 2023-02-09 WO disclosed
WO-2022126000-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 Design Therapeutics, Inc. (US) 2022-06-16 WO disclosed
WO-2009060208-A1 PYRROLOBENZODIAZEPINES SPIROGEN LIMITED (GB) 2009-05-14 WO disclosed
WO-2009060215-A1 POLYAMIDES SPIROGEN LIMITED (GB) 2009-05-14 WO disclosed