Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649757 | 0.85 | PRKAA2 (0.49) | DRD4DRD2TEAD1HTR2APRKAA2 | |
| SCHEMBL650342 | 0.85 | PRKAA2 (0.49) | DRD4DRD2TEAD1HTR2APRKAA2 | |
| SCHEMBL649758 | 0.85 | PRKAA2 (0.49) | DRD4DRD2TEAD1HTR2APRKAA2 | |
| SCHEMBL12265115 | 0.82 | USP30 (0.54) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL12265085 | 0.81 | CHRM4 (0.53) | HIF1AEPAS1DRD4TEAD1PRKAA2 | |
| SCHEMBL648104 | 0.80 | SLC6A5 (0.53) | DRD4TEAD1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL649469 | 0.80 | PRKAA2 (0.47) | HIF1AEPAS1DRD4DRD2TEAD1 | |
| SCHEMBL647268 | 0.80 | PRKAA2 (0.53) | DRD4DRD2TEAD1HTR2APRKAA2 | |
| SCHEMBL647024 | 0.80 | PRKAA2 (0.53) | DRD4DRD2TEAD1HTR2APRKAA2 | |
| SCHEMBL647025 | 0.80 | PRKAA2 (0.53) | DRD4DRD2TEAD1HTR2APRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |