Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845734 | 0.84 | CYP3A4 (0.51) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31644815 | 0.81 | CYP3A4 (0.53) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260368 | 0.80 | CYP3A4 (0.51) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260413 | 0.79 | TSHR (0.48) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260325 | 0.79 | TSHR (0.50) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL21111957 | 0.79 | TSHR (0.50) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260382 | 0.78 | CYP3A4 (0.46) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260378 | 0.77 | TSHR (0.48) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL31260359 | 0.77 | CYP3A4 (0.48) | TSHRCYP3A4TDP1ATMLMNA | |
| SCHEMBL2881274 | 0.77 | CYP3A4 (0.59) | TSHRCYP3A4TDP1ATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |