Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041576 | 0.80 | MAPT (0.54) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL28669892 | 0.78 | NPC1 (0.63) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL3739365 | 0.77 | PARP1 (0.53) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL13041440 | 0.76 | EPHX2 (0.54) | MAPTKMT2ANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL4104057 | 0.74 | EPHX2 (0.55) | MAPTNPC1SMN1; SMN2EPHX2POLB | |
| SCHEMBL18138936 | 0.73 | POLB (0.51) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL9965417 | 0.73 | EPHX2 (0.57) | MAPTKMT2ANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL1768978 | 0.72 | KMT2A (0.51) | KMT2AMEN1NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10838945 | 0.72 | SMN1; SMN2 (0.48) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL15528518 | 0.72 | ALDH1A1 (0.67) | NPC1ALDH1A1LMNAKDM4ECETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061676-A2 | ANTAGONISTS OF PGD2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |