Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846093 | 1.00 | HTR4 (0.53) | HTR4CHRNB2CHRNA4HDAC4HDAC6 | |
| SCHEMBL3544670 | 0.94 | HTR4 (0.54) | HTR4MCHR1USP30CHRM4CHRM5 | |
| SCHEMBL13846090 | 0.94 | HTR4 (0.54) | HTR4MCHR1USP30CHRM4CHRM5 | |
| SCHEMBL13175736 | 0.94 | HTR4 (0.54) | HTR4MCHR1USP30CHRM4CHRM5 | |
| SCHEMBL13880647 | 0.91 | AURKA (0.52) | HTR4MCHR1PTK2 | |
| SCHEMBL13175766 | 0.89 | HTR4 (0.50) | HTR4USP30CHRM4CHRM5ADRA2C | |
| SCHEMBL28477021 | 0.89 | HDAC4 (0.46) | HTR4CHRNB2CHRNA4HDAC4HDAC6 | |
| SCHEMBL738237 | 0.87 | HTR4 (0.53) | HTR4MCHR1PTK2 | |
| SCHEMBL12825174 | 0.85 | KMT2A (0.57) | — | |
| SCHEMBL1927002 | 0.85 | KMT2A (0.54) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |