Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 7/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3309310 | 0.91 | ABL1 (0.46) | SYKBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL3309348 | 0.83 | JAK1 (0.49) | SYKMTORSMG1ABL1PDGFRB | |
| SCHEMBL3316015 | 0.83 | JAK2 (0.48) | BMPR1BMTORSMG1ABL1PDGFRB | |
| SCHEMBL3310237 | 0.83 | JAK2 (0.48) | BMPR1BMTORSMG1ABL1PDGFRB | |
| SCHEMBL2356980 | 0.82 | CDK2 (0.49) | SYKBMPR1BABL1KITBCR | |
| SCHEMBL3312256 | 0.82 | JAK2 (0.48) | BMPR1BMTORSMG1ABL1KIT | |
| SCHEMBL2359371 | 0.81 | JAK2 (0.47) | BMPR1BMTORSMG1ABL1PDGFRB | |
| SCHEMBL13846245 | 0.81 | ABL1 (0.53) | ABL1PDGFRBBCRSRCPDGFRA | |
| SCHEMBL3377981 | 0.81 | SYK (0.43) | SYKBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2356206 | 0.81 | JAK2 (0.45) | SYKBMPR1BMTORSMG1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |