Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | BCR | P11274 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | PRKACB | P22694 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301729 | 0.90 | JAK2 (0.54) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL13846259 | 0.81 | SYK (0.45) | ABL1BCRSRCEGFRCDK2 | |
| SCHEMBL13846251 | 0.81 | STK17A (0.46) | ABL1BCRSRCEGFRCAMK2D | |
| SCHEMBL13846277 | 0.80 | JAK2 (0.43) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2358226 | 0.79 | CCNE1 (0.57) | ABL1PRKACACAMK2DPLK1CDK2 | |
| SCHEMBL2363861 | 0.79 | ABL1 (0.49) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2356289 | 0.79 | JAK2 (0.58) | ABL1EGFRPRKACACAMK2DPLK1 | |
| SCHEMBL2356563 | 0.78 | JAK2 (0.55) | ABL1BCRSRCPRKACACAMK2D | |
| SCHEMBL17451314 | 0.78 | ABL1 (0.53) | ABL1BCRSRCPRKACACAMK2D | |
| SCHEMBL2357620 | 0.78 | ABL1 (0.52) | ABL1BCRSRCPRKACACAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |