Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658655 | 0.90 | JAK2 (0.56) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL13846220 | 0.88 | CDK2 (0.53) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL13846270 | 0.87 | PRKCQ (0.43) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL13846293 | 0.85 | IRAK4 (0.44) | JAK2TYK2CCNE1CDK2CCNT1 | |
| SCHEMBL13846263 | 0.85 | IRAK4 (0.44) | JAK2TYK2CCNE1CDK2CCNT1 | |
| SCHEMBL13846297 | 0.84 | LRRK2 (0.43) | JAK2TYK2CCNE1CDK2CCNT1 | |
| SCHEMBL13846291 | 0.84 | FFAR1 (0.39) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL13846369 | 0.84 | LRRK2 (0.46) | JAK2CDK2CCNT1CDK1CCNB1 | |
| SCHEMBL13846280 | 0.84 | LRRK2 (0.44) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL13846362 | 0.83 | LRRK2 (0.44) | JAK2TYK2CCNE1CDK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |