Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 8/20 | 0.42 |
| ▸ | CHUK | O15111 | 8/20 | 0.42 |
| ▸ | IKBKG | Q9Y6K9 | 8/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846266 | 0.96 | JAK2 (0.44) | SYKIKBKBCHUKIKBKGCDK2 | |
| SCHEMBL3715052 | 0.92 | CDK2 (0.48) | SYKIKBKBCHUKIKBKGCDK1 | |
| SCHEMBL13846365 | 0.92 | JAK2 (0.43) | CDK1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3306129 | 0.89 | CDK2 (0.47) | CDK1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3719453 | 0.88 | JAK2 (0.46) | SYKCDK2JAK2JAK1JAK3 | |
| SCHEMBL13846212 | 0.87 | JAK2 (0.48) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL3310409 | 0.87 | CDK2 (0.51) | IKBKBCDK1CDK2JAK2JAK1 | |
| SCHEMBL13846262 | 0.86 | JAK2 (0.44) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL3313253 | 0.85 | CDK2 (0.48) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL3310492 | 0.85 | CCNE1 (0.51) | IKBKBCHUKIKBKGCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |