Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | OPA1 | O60313 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846266 | 0.96 | JAK2 (0.44) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL3717901 | 0.94 | JAK2 (0.45) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL13846296 | 0.92 | SYK (0.42) | JAK2JAK3JAK1CDK2ROCK2 | |
| SCHEMBL3719453 | 0.90 | JAK2 (0.46) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL13846361 | 0.90 | CDK1 (0.43) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL3306129 | 0.89 | CDK2 (0.47) | JAK2JAK3JAK1CDK2ROCK2 | |
| SCHEMBL13846212 | 0.89 | JAK2 (0.48) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL13846262 | 0.89 | JAK2 (0.44) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL13846272 | 0.88 | CDK1 (0.43) | JAK2JAK3JAK1CDK2IKBKE | |
| SCHEMBL3310409 | 0.87 | CDK2 (0.51) | JAK2JAK3JAK1CDK2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |