Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 7/20 | 0.43 |
| ▸ | CCNK | O75909 | 3/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | CHUK | O15111 | 4/20 | 0.40 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846262 | 0.96 | JAK2 (0.44) | CDK1CDK2JAK2JAK3JAK1 | |
| SCHEMBL13846212 | 0.92 | JAK2 (0.48) | CDK1CDK2JAK2JAK3JAK1 | |
| SCHEMBL3709989 | 0.91 | JAK2 (0.45) | CDK1CDK2JAK2JAK3JAK1 | |
| SCHEMBL13846365 | 0.90 | JAK2 (0.43) | CDK1CDK2JAK2CCNKCDK12 | |
| SCHEMBL13846272 | 0.90 | CDK1 (0.43) | CDK1CDK2JAK2CCNKCDK12 | |
| SCHEMBL13846266 | 0.89 | JAK2 (0.44) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13595268 | 0.89 | IKBKB (0.44) | CDK1CDK2JAK2CCNKCDK12 | |
| SCHEMBL3719159 | 0.86 | JAK2 (0.46) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL4408483 | 0.86 | CDK2 (0.47) | CDK1CDK2JAK2CCNKCDK12 | |
| SCHEMBL2358934 | 0.86 | CDK2 (0.47) | CDK1CDK2JAK2CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |