Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14598905 | 1.00 | PTGS2 (0.54) | PTGS2ESR2 | |
| SCHEMBL13847027 | 0.92 | ESR2 (0.51) | PTGS2ESR2 | |
| SCHEMBL14598900 | 0.92 | PTGS2 (0.45) | PTGS2ESR2 | |
| SCHEMBL14598904 | 0.89 | PTGS2 (0.50) | PTGS2ESR2 | |
| SCHEMBL6385654 | 0.89 | ESR2 (0.59) | PTGS2ESR2 | |
| SCHEMBL14598902 | 0.89 | ESR2 (0.59) | PTGS2ESR2 | |
| SCHEMBL13846903 | 0.89 | PTGS2 (0.43) | PTGS2ESR2 | |
| SCHEMBL14598901 | 0.89 | ESR2 (0.59) | PTGS2ESR2 | |
| SCHEMBL13846900 | 0.89 | PTGS2 (0.43) | PTGS2ESR2 | |
| SCHEMBL6385661 | 0.89 | ESR2 (0.59) | PTGS2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601644-B1 | NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST COMPANY (CA) | 2009-05-27 | — | — | EP | disclosed |
| US-7169809-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST COMPANY (CA) | 2007-01-30 | — | — | US | disclosed |