Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 19/20 | 0.71 |
| ▸ | EDNRA | P25101 | 19/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386681 | 0.93 | EDNRB (0.67) | EDNRBEDNRA | |
| SCHEMBL7831450 | 0.87 | EDNRA (0.55) | EDNRBEDNRA | |
| SCHEMBL7831454 | 0.87 | EDNRA (0.55) | EDNRBEDNRA | |
| SCHEMBL7483156 | 0.86 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL5493621 | 0.83 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL1383307 | 0.82 | EDNRA (0.74) | EDNRBEDNRA | |
| SCHEMBL1386066 | 0.81 | EDNRB (0.58) | EDNRBEDNRA | |
| SCHEMBL7841108 | 0.81 | EDNRA (0.48) | EDNRBEDNRA | |
| SCHEMBL7841111 | 0.81 | EDNRA (0.48) | EDNRBEDNRA | |
| SCHEMBL14289233 | 0.81 | EDNRB (1.00) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4832706-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| EP-1309564-B1 | ARYLETHENE-SULFONAMIDES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-14 | — | — | EP | claimed |